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Revolution in Canine Care: The Dawn of Anti-Aging Treatment for Large Dogs



In an era where medical science is leaping forward, a groundbreaking development from San Francisco’s biotech world is setting tails wagging. The U.S. Food and Drug Administration (FDA) is on the verge of approving a drug that promises not just a longer leash on life for large-breed dogs but better quality years. It’s a development that could redefine canine care.

LOY-001: A Leap for Dogkind

The brainchild of the biotech company Loyal, the drug, known as LOY-001, is on the fast track to becoming the first FDA-approved medication for extending the lifespan of our furry friends. With over 25 million large-breed dogs in the U.S., the potential impact is enormous.

How Does It Work? Tackling Aging at Its Core

The secret to LOY-001’s potential lies in its unique approach. It targets the hormone IGF-1, which accelerates aging, intending to prevent age-related canine diseases before they manifest. “Think of it as a time machine in a syringe,” joked Loyal CEO Celine Halioua in a recent statement.

FDA’s Nod: A Step Closer to Reality

Loyal announced that LOY-001 had cleared early hurdles with the FDA, showing promising effectiveness data. However, there’s still a journey ahead, including a large clinical trial and a comprehensive review of safety and manufacturing data.

The Aging Dilemma: Why Big Dogs Age Faster

For large-breed dogs, the tick-tock of the biological clock is a bit louder and faster. The growth-promoting hormone IGF-1, found at higher levels in large dogs, is believed to play a significant role in accelerating aging and reducing lifespan. LOY-001 aims to target this very hormone.

Groundbreaking, But With a Side of Caution

Veterinarians across the board are cautiously optimistic. Dr. Ivana Crnec, a Texas-based veterinarian, sees LOY-001 as a potential game-changer. “It’s like we’ve finally cracked a code in canine longevity,” she said. Meanwhile, Dr. Jeffrey Krasnoff expressed his intrigue, “If this works, it’s a dog lover’s dream come true.”

A New Era of Treatment: Pill Form on the Horizon

Currently administered via injection every three to six months, Loyal is also developing a daily pill form of LOY-001. This shift could make the treatment more accessible and easier for pet owners to manage.

Anticipated Launch: A 2026 Debut

Subject to FDA’s nod on manufacturing and safety, LOY-001 is expected to hit the market in 2026. This timeline means hope is on the horizon for pet parents dreaming of more golden years with their large canine companions.

A Pawsitive Future Ahead

As we wait for the final word from the FDA, the buzz around LOY-001 continues to grow. This isn’t just a drug; it’s a potential new chapter in the way we care for our canine companions, promising a future where “growing old together” takes on a whole new meaning for dogs and their humans.

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All-Argentine Affair as Báez Overpowers Navone to Win Rio Open



The Argentine Sebastián Báez won his first ATP 500 title on Sunday by defeating his compatriot Mariano Navone in the Rio de Janeiro tournament final, the main event in South America. The fifth seed and world number 30, which will climb nine positions, the right-hander 23-year old imposed authority by 6-2 and 6-1.

He came to have a 4-0 lead in both sets of a match settled in one hour and 22 minutes on the clay court of the central court of the Jockey Club, with capacity for 6,200 spectators.

“The beginning of the sets was important, that’s where I took the lead and I guess on Mariano’s side it became a little difficult, beyond the score, the nerves matter a little more in your first final,” he said.

The Buenos Aires native, son of a veteran of the Malvinas War (1982), achieved the greatest achievement of his career in his third participation in the hot and humid Rio competition.

He won his fifth ATP Tour title in the first all-Argentine final of the event and in an unprecedented duel against his 22-year-old compatriot, the great revelation by advancing from qualifying to the decisive match.

Before the game, his trophy case held four circuit trophies: Winston-Salem, Kitzbühel and Córdoba in 2023 and Estoril in 2022, all ATP 250 category.

He is now part of a select group that was consecrated on the city’s clay, such as Spaniards Rafael Nadal (2014), David Ferrer (2015) and Carlos Alcaraz (2022) or Argentine Diego Schwartzman (2018).

Semi-clear path

In the tenth edition of the Rio ATP 500, which has never repeated champion, Báez had a semi-clear path thanks largely to the early withdrawal of Carlos Alcaraz, 20 years old.

The world number two and top favorite shared the main draw path with the newly crowned winner, but withdrew in the first round due to injury.

Despite Alcaraz’s absence, the Argentine had solid performances and left behind Frenchman Corentin Moutet (147) in the first round 6-4 and 6-3 and his compatriot Facundo Díaz Acosta (59), champion of the Buenos Aires tournament, in the round of 16 by 7-6 (7/1) and 6-3.

In the quarterfinals he got rid of Brazilian Thiago Monteiro (117) by 6-4, 1-6 and 2-6 and in the semifinals he dispatched the best racket in Argentina, Francisco Cerúndolo (22), with a resounding 7-5 and 6- 0.

In the title match, he repeated the dose to the surprising Navone (113, will move to 60) and consolidated a good start to the year after reaching the semis in Córdoba and the quarters in Buenos Aires.

The surprise

Born in the small town of 9 de Julio, in the interior of the province of Buenos Aires, Navone starred in two upsets on the way to disputing his first ATP Tour final.

In the quarterfinals he eliminated promising 17-year-old Brazilian Joao Fonseca (655), and in the semis he beat defending champion and favorite after Alcaraz’s departure, Briton Cameron Norrie (23).

Báez and Navone are part of the list of tennis players participating next week in the ATP 250 tournament in Santiago, Chile, the last stop on the South American clay court tour.

But Navone doubted his attendance due to mental fatigue.

The Rio tournament also crowned its doubles champions on Sunday: Colombian Nicolás Barrientos and Brazilian Rafael Matos beat Austrians Lucas Miedler and Alex Erler 6-4 and 6-3.

Matos, 28, became the first local to win the tournament.

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What is it Like to Live in Costa Rica?This is What National Geographic Says About our Country ⋆ The Costa Rica News



In its Travel edition, the prestigious international magazine National Geographic recounted what it is like to live in the country of “Pura Vida”.The journalist José Alejandro Adamuz detailed in an article in the publication his experience on the beach, but also in the city and other points.

These are the observations he made at various points:


The friendliness and hospitality of Costa Ricans are aspects that define the experience of traveling in Costa Rica, especially for those who decide to travel alone. The usual warmth and friendly treatment of people creates a welcoming atmosphere, making travelers feel safe and cared for.


Costa Rica’s reputation as one of the safest countries in Latin America is real. Yes, even in Chepe. They have been one of the favorite destinations for North American tourists for years and this is evident in the hotel infrastructure. Additionally, the efficient and affordable public transportation system makes it easy to get anywhere in the country. (…) There, if you tell the driver to let you know when he is close to the place you are going, you can be sure that he will let you know. Not only him, surely everyone in the passage will do the same.


Exploring Costa Rica by car provides a unique freedom to discover stunning landscapes at your own pace. You never know when a Caribbean sunset is going to make you want to stay on the beach until the night dragonflies appear. However, it is crucial to take precautions, such as avoiding stopping in lonely places in case of mechanical problems. It is advisable to always use navigation devices, in addition to renting a 4×4 because they perform well on any road and situation. Sometimes the terrain in Costa Rica can be more adventurous than one expects (or would like).


You have to try pejibaye, jocote or mamón. I remember what they told me once in a fruit shop: Everything from Costa Rico, only the grapes are from Peru. Costa Rican gastronomy is a feast for the senses, with influences from Latin and Caribbean cuisine.

Drinking water

This is a small detail that fascinated me: not depending on finding a store to buy bottled water to drink. Although bottled water is more recommended for short-stay travelers to avoid possible gastrointestinal problems, when you have been in Costa Rica for a while, you can drink tap water without a problem.

Connection with other travelers

The demand for security, hospitality and nature makes Costa Rica a country where many travelers tend to converge, so the ease of meeting people along the way skyrockets and is one of the biggest secrets of traveling alone through Costa Rica. Hostels and hostels become ideal meeting points for socializing.

Challenge Directions

The peculiar address system in Costa Rica, based on physical reference points, sometimes with the added problem that they can be references from the past, ranging from a church, a bar, a grocery store or a school, can be disconcerting for Travellers. Although in San José, for example, the streets and avenues are numbered, people usually give the address “tico”.

Spanish, Tico and English

As in the rest of Central America, the predominant language is Spanish. However, Costa Rica has a long tradition of receiving American tourists, so it is normal for English to be used in the tourism ecosystem for much more than just announcing vacant rooms. It may not be something to take into account for Spanish travelers, but it is one of the reasons why Costa Rica welcomes so many travelers from all over the world: it is easy to communicate with Ticos.

Pure Life dude

“Puravida” is not just an expression or a cliché, but an entire way of life in Costa Rica. Used to greet, say thank you or say goodbye, it represents a philosophy of a relaxed, calm and happy life, anyone’s dream. This mentality positive transcends from orality to the travel experience.

Resonance Costa Rica
At Resonance, we aspire to live in harmony with the natural world as a reflection of our gratitude for life. Visit and subscribe at Resonance Costa Rica Youtube Channel

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6,000 Costa Ricans Die Each Year from Cancer but the Number Could Double in Less Than Two Decades, Experts Warn ⋆ The Costa Rica News



In Costa Rica each year, more than 13,000 people are diagnosed with cancer and more than 6,000 die from this disease.According to the World Health Organization (WHO), by 2040, the number of new cases and deaths in the country will almost double.

This drastic increase would occur if actions are not taken promptly and decisively to stop the avalanche of cancer cases and deaths that could occur. That is what specialists Warner Alpízar, an expert in tumor biology at the University of Costa Rica, and Luis Bermúdez, from the Robotic Radiosurgery Center, consider.

“Thanks to improvements in social and health conditions, life expectancy has increased substantially,” they highlight.“However, living longer leads to a longer exposure time to environmental and lifestyle factors strongly associated with the risk of developing cancer,” both warn.

Researchers list a series of elements as possible causes of diseases such as cancer. Among them they mention:




Prolonged exposure to ultraviolet light

Excessive alcohol intake

Early diagnosis:

According to experts, to stop these growing trends, efforts must be redoubled in early diagnosis.“We have to take into account that early detection by itself does not bear fruit if it is not part of a more comprehensive strategy, which also reinforces timely access to treatment and prevention,” they consider.

They emphasize that it is essential to guarantee that people suspected or already diagnosed will receive expeditious and more efficient treatment for their disease.“And while the patient waits, the disease progresses, which reduces their chances of survival, impairs their quality of life and makes treatment more expensive,” they lament.

Cancer Advancement

As the cancer grows in size, the cancer cells accumulate more mutations – DNA damage, their instruction manual.“Therefore, the diversity of malignant cells increases and this affects the growth and degree of tumor aggressiveness. With this, it is increasingly likely that resistance to anticancer therapies will emerge,” the specialists explain.

Over time, the likelihood of cancer cells breaking away from the primary tumor, spreading to other sites in the body, and forming metastases also increases,” they added.This situation is key in the management of the disease. It is estimated that 90% of cancer deaths are due to metastatic cases.

Nutrient depletion

Another aspect that worsens over time is the uncontrolled growth of cancer cells, which excessively and inefficiently consume the nutrients that are necessary for the healthy cells that make up the body’s tissues.

“The larger the cancer, the more the person’s physical condition deteriorates, because normal cells are left without the necessary inputs for their functions,” the doctors detail.

Taken together, the biological factors make it clear that a cancer detected and treated late is synonymous with a more aggressive disease, which worsens the probability of survival, quality of life and increases the cost of care for the health system.

Diagnosis and treatment

Epidemiological studies have shown in practice that the time between diagnosis and treatment of a cancer patient is critical if mortality is to be reduced.For example, a 2020 study concluded that for every month of delay in the treatment of a person with this condition, the risk of death increases by about 10%.

Doctors consider that in Costa Rica it is necessary to define strategies that reduce the time that elapses from when a patient is referred for suspicion until treatment.In first world countries such as Iceland, New Zealand and the United Kingdom, the target time between referral for suspicion and treatment is eight weeks, while the period between diagnosis and treatment is four weeks.

“There are no times”

“If we look at the case of Costa Rica, there is no target time at the country level in the path of the cancer patient. In addition to this, each region and hospital in the country has different management,” the specialists highlight.

According to the consensus of three national oncologists, who were consulted, in Costa Rica there are no statistics on the average time that passes between the referral for suspected cancer and the patient’s treatment.In some hospitals the time between diagnosis and treatment could be four weeks, the time between suspicion and diagnosis can be several months.

“One of the causes of this is due to the lack of specialists, which leads to enormous waiting lists and deadlines for reporting procedures of six months to a year,” the two experts acknowledge.

“This situation is alarming. If for every month of delay in the treatment of the disease the risk of death increases by 10%, as the study showed, in Costa Rica cancer patients could have a risk of mortality that is up to 50% higher, compared to other countries“, they point out.

This could be one of the reasons why, despite the fact that diagnosis has been improved, the incidence of cases is similar to first world countries, but the cancer mortality rate is the second highest in Central America and Mexico and similar to that of Honduras.

For specialists, a change is urgently needed in Costa Rica to reduce the increase in incidence and mortality. Some of the actions they recommend are:

Attack the structural problems that the health system currently presents

Improve access to services

Guarantee the training of more specialists

Reduce waiting times

Invest in cutting-edge technologies

Streamline bureaucratic systems with the intention of guaranteeing patient access to the most effective treatments currently available

“In summary, it is crucial to establish a country goal in the path of the cancer patient, because although time heals wounds, in the fight against cancer, time is our worst enemy,” they concluded.

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